Chrysin, a natural flavone, improves murine inflammatory bowel diseases.

Abstract

Chrysin (5,7-dihydroxyflavone) is a natural flavone commonly found in many plants. It has previously been shown to be an anti-tumor agent. In this study, we investigated whether chrysin could alleviate the symptoms of dextran sodium sulfate (DSS)-induced colitis in mice and whether chrysin has an inhibitory effect on nuclear factor (NF)-kappaB activation in vitro. A significant blunting of weight loss and clinical signs was observed in DSS-exposed, chrysin-treated mice when compared to vehicle-treated mice. This was associated with a remarkable amelioration of the disruption of the colonic architecture, a significant reduction in colonic myeloperoxidase (MPO) activity, and a decrease in the production of inflammatory mediators such as nitric oxide (NO), prostaglandin (PG) E(2), and pro-inflammatory cytokines. In addition, chrysin inhibited tumor necrosis factor (TNF)-alpha-induced activation of NF-kappaB in IEC-6 cells. These findings suggest that chrysin exerts potentially clinically useful anti-inflammatory effects mediated through the suppression of NF-kappaB activation.

• Authors: Eun Kyung Shin, Hyuck-Se Kwon, Yoon Hee Kim, Hyun-Kyung Shin, Jin-Kyung Kim
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 381 Issue 4 Pg. 502-7 (Apr 17 2009) ISSN: 1090-2104 [Electronic] United States
• PMID: 19233127 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Flavonoids
• I kappa B beta protein
• I-kappa B Proteins
• Inflammation Mediators
• chrysin
• Dextran Sulfate

Topics

• Animals
• Colon (drug effects, metabolism, pathology)
• Dextran Sulfate (toxicity)
• Disease Models, Animal
• Flavonoids (therapeutic use)
• I-kappa B Proteins (metabolism)
• Inflammation Mediators (metabolism)
• Inflammatory Bowel Diseases (chemically induced, drug therapy, pathology)
• Intestinal Mucosa (drug effects, metabolism, pathology)
• Mice
• Mice, Inbred BALB C
• Protein Transport (drug effects)
• Weight Loss (drug effects)