Ciprofloxacin monotherapy for acute pelvic infections: a comparison with clindamycin plus gentamicin.

Abstract

This prospective, randomized controlled study compared the efficacy and safety of ciprofloxacin alone versus a conventional two-drug regimen, clindamycin with gentamicin. The study group included 71 patients hospitalized for pelvic infections such as acute (N = 33) and chronic (N = 8) salpingitis, tubo-ovarian abscesses (N = 11), endometritis (N = 9), septic abortion (N = 3), and other categories (N = 7). Twenty-two of 35 patients on ciprofloxacin and 20 of 36 on clindamycin plus gentamicin had culturable pathogens: gonococci in 28, anaerobes in six, chlamydia in four, and associated pathogens in 19. Complete clinical and bacteriologic cure was achieved in 21 of 22 (95%) in the ciprofloxacin group and 19 of 20 (95%) in the clindamycin plus gentamicin group. The mean duration of intravenous/oral ciprofloxacin therapy was 3.7/7.2 days, and it was 3/6.6 days for clindamycin plus gentamicin. Ciprofloxacin, a new quinolone, appears to be safe as a single-drug therapy and was as effective as the combination of clindamycin plus gentamicin for the treatment of severe pelvic infections requiring hospitalization.

• Authors: H Thadepalli, D Mathai, R Scotti, M B Bansal, E Savage
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 78 Issue 4 Pg. 696-702 (Oct 1991) ISSN: 0029-7844 [Print] United States
• PMID: 1923175 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Gentamicins
• Clindamycin
• Ciprofloxacin

Topics

• Acute Disease
• Adolescent
• Adult
• Ciprofloxacin (therapeutic use)
• Clindamycin (administration & dosage, therapeutic use)
• Drug Therapy, Combination
• Female
• Gentamicins (administration & dosage, therapeutic use)
• Humans
• Pelvic Inflammatory Disease (drug therapy, microbiology)
• Prospective Studies