Usefulness of fatty meal-stimulated cholescintigraphy in the diagnosis and treatment of chronic acalculous cholecystitis.

Abstract

OBJECTIVE:

Fatty meal cholescintigraphy (fatty meal CS) is a potential physiologic alternative for cholecystokinin (CCK) CS in the diagnosis and treatment of chronic acalculous cholecystitis (CAC). However, there are limited data in the literature to support this assumption. Our objective was to determine the usefulness of fatty meal CS in the diagnosis and treatment of CAC.

METHODS:

We retrospectively reviewed the medical records of 198 patients who had undergone fatty meal CS for presumed CAC. Data retrieved focused on symptom improvement following management. Gallbladder ejection fraction (GBEF) of 50% or less was considered abnormal. Patients were divided into groups on the basis of test results and management.

RESULTS:

In group 1a, patients with low GBEF and cholecystectomy, 88% (54 of 61) reported symptom improvement, whereas the remaining 12% (7 of 61) retained their symptoms. Group 1b consisted of patients with low GBEF and who were managed medically. Persistence of symptoms was noted in 76% (32 of 42) of patients, whereas the remaining 24% (10 of 42) had symptom improvement. Group 2 consisted of patients with normal GBEF. Follow-up showed that 60% (47 of 78) of patients had symptom improvement either spontaneously or on medical treatment, whereas the remaining 40% (31 of 78) retained their symptoms.

CONCLUSIONS:

Fatty meal CS is a very useful technique in the diagnosis of CAC. It predicts a good surgical outcome once GBEF is low in patients with high pre-test probability for CAC. Moreover, fatty meal CS may be a good alternative to CCK CS.

• Authors: Kusai Al-Muqbel, Mohammed Bani Hani, Mohammad Daradkeh, Abdullah Rashdan
• Journal: Annals of nuclear medicine (Ann Nucl Med) Vol. 23 Issue 2 Pg. 137-42 (Feb 2009) ISSN: 0914-7187 [Print] Japan
• PMID: 19225936 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Dietary Fats

Topics

• Acalculous Cholecystitis (diagnostic imaging, diet therapy)
• Chronic Disease
• Dietary Fats (therapeutic use)
• Female
• Humans
• Image Enhancement (methods)
• Male
• Middle Aged
• Radionuclide Imaging
• Reproducibility of Results
• Retrospective Studies
• Sensitivity and Specificity
• Treatment Outcome