[Long-term remission of a nasal NK/T-cell lymphoma patient with massive involvement of the orbita and liver dysfunction].

Abstract

A 49-year-old woman with high fever and diffuse swelling of the right cheek was referred to our hospital. Computed tomography showed right orbital tumor with massive involvement. Histopathologic examination of the biopsied right orbital tumor demonstrated extranodal NK/T-cell lymphoma, nasal-type. She was treated with six courses of chemotherapy consisting of etoposide and dexamethasone with 50 Gy of concurrent involved-field radiotherapy. Facial swelling and liver dysfunction improved immediately, and after five courses of chemotherapy, she achieved partial remission without any severe adverse events. L-asparaginase was administered in the final course of chemotherapy. There is no evidence of recurrence 56 months after diagnosis.

• Authors: Fumihiko Monma, Satoshi Ueno, Motoko Yamaguchi, Isao Tawara, Kana Miyazaki, Kazuhiro Nishii, Kazunori Nakase, Naoyuki Katayama
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 50 Issue 1 Pg. 44-8 (Jan 2009) ISSN: 0485-1439 [Print] Japan
• PMID: 19225229 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Etoposide
• Dexamethasone
• Asparaginase

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Asparaginase (administration & dosage)
• Combined Modality Therapy
• Dexamethasone (administration & dosage)
• Etoposide (administration & dosage)
• Female
• Humans
• Liver Diseases (complications)
• Lymphoma, Extranodal NK-T-Cell (complications, drug therapy, radiotherapy)
• Middle Aged
• Neoplasm Invasiveness
• Nose Neoplasms (complications, drug therapy, pathology, radiotherapy)
• Orbital Neoplasms (complications, drug therapy, pathology, radiotherapy)
• Radiotherapy Dosage
• Remission Induction
• Time Factors
• Treatment Outcome