Polychlorinated biphenyls and risk of testicular germ cell tumors.

Abstract

Exposure to endocrine-disrupting chemicals, such as polychlorinated biphenyls (PCB), may alter hormonal balance and thereby increase risk of testicular germ cell tumors (TGCT). To study the relationship of PCBs to TGCT, prediagnostic serum samples from 736 cases and 913 controls in the Servicemen's Testicular Tumor Environmental and Endocrine Determinants study were analyzed. Adjusted odds ratios and 95% confidence intervals were estimated using logistic regression. PCB levels were examined in association with all TGCT and, separately, with each histologic type (seminoma and nonseminoma). Risks associated with seven functional groupings of PCBs, as well as sum of PCBs, were also examined. There were significantly decreased risks of TGCT in association with eight PCBs (PCB-118, PCB-138, PCB-153, PCB-156, PCB-163, PCB-170, PCB-180, and PCB-187) and no association with the remaining three (PCB-99, PCB-101, and PCB-183). The same eight congeners were significantly associated with decreased risk of nonseminoma, whereas five (PCB-138, PCB-153, PCB-156, PCB-163, and PCB-170) were associated with decreased risk of seminoma. All functional groupings of PCBs were also associated with decreased risk of TGCT and of nonseminoma, whereas six of the seven functional groups were associated with decreased risk of seminoma. Sum of PCBs was significantly associated with decreased risk of TGCT (P(trend) = 0.006), nonseminoma (P(trend) = 0.007), and seminoma (P(trend) = 0.05). Overall, these data do not support the hypothesis that PCB exposure increases the risk of TGCT.

• Authors: Katherine A McGlynn, Sabah M Quraishi, Barry I Graubard, Jean-Philippe Weber, Mark V Rubertone, Ralph L Erickson
• Journal: Cancer research (Cancer Res) Vol. 69 Issue 5 Pg. 1901-9 (Mar 01 2009) ISSN: 1538-7445 [Electronic] United States
• PMID: 19223531 (Publication Type: Journal Article, Research Support, N.I.H., Intramural)

Chemical References

• Dichlorodiphenyl Dichloroethylene
• Polychlorinated Biphenyls

Topics

• Adolescent
• Adult
• Age Factors
• Dichlorodiphenyl Dichloroethylene (toxicity)
• Humans
• Hypospadias (chemically induced)
• Male
• Middle Aged
• Neoplasms, Germ Cell and Embryonal (chemically induced)
• Polychlorinated Biphenyls (toxicity)
• Risk
• Testicular Neoplasms (chemically induced)