Immunoexpression of keratins in the calcifying cystic odontogenic tumor epithelium.

Abstract

Ameloblastomatous epithelium containing clusters of ghost cells is the typical histopathology of calcifying cystic odontogenic tumor (CCOT). This paper aimed to assess keratins AE1-AE3, K7, K10/13, K14, K18, K19, vimentin, laminin, and collagen IV in 08 CCOTs to discuss their histopathogenesis. Similarity to the immunoprofile of the stratified squamous epithelium was seen in the with the basal layer expressing K14 and the upper cells expressing K10/13. When compared to the immunoprofile of the normal odontogenic epithelium, of odontogenic tumor epithelia and of the ghost cells described in the literature, it was possible to suggest that the CCOT epithelium differentiates towards squamous type.

• Authors: Marcelo Macedo Crivelini, Renata Callestini Felipini, Gilberto Aparecido Coclete, Ana Maria Pires Soubhia
• Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 38 Issue 4 Pg. 393-6 (Apr 2009) ISSN: 1600-0714 [Electronic] Denmark
• PMID: 19222713 (Publication Type: Journal Article)

Chemical References

• Collagen Type IV
• Laminin
• Vimentin
• Keratins

Topics

• Cell Differentiation
• Cell Transformation, Neoplastic
• Collagen Type IV (biosynthesis)
• Epithelium (metabolism)
• Humans
• Immunohistochemistry
• Jaw Neoplasms (metabolism, pathology)
• Keratins (biosynthesis)
• Laminin (biosynthesis)
• Odontogenic Cyst, Calcifying (metabolism, pathology)
• Vimentin (biosynthesis)