Dichloroacetonitrile, a by-product of water chlorination, induces aneuploidy in Drosophila.

Abstract

Nitriles have been shown to be potent inducers of aneuploidy in yeast and Drosophila test systems. Haloacetonitriles are by-products of water chlorination that have been shown to be mutagenic and carcinogenic following topical application. In this report we show that dichloroacetonitrile, but not dibromoacetonitrile, is an effective inducer of aneuploidy in oocytes of Drosophila melanogaster. Following inhalation exposure of ZESTE adult females, dichloroacetonitrile (8.6 ppm) induced highly significant increments in the frequencies of sex chromosome loss and gain. Sodium cyanide was also found to be a highly effective inducer of germline aneuploidy, suggesting that cyanide toxicity may contribute to potency of nitriles as inducers of aneuploidy.

• Authors: C Osgood, D Sterling
• Journal: Mutation research (Mutat Res) Vol. 261 Issue 2 Pg. 85-91 (Oct 1991) ISSN: 0027-5107 [Print] Netherlands
• PMID: 1922159 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acetonitriles
• dichloroacetonitrile
• Sodium Cyanide
• dibromoacetonitrile

Topics

• Acetonitriles (toxicity)
• Administration, Inhalation
• Aneuploidy
• Animals
• Drosophila (genetics)
• Female
• Male
• Mutagenicity Tests
• Sodium Cyanide (pharmacology)
• Time Factors