The relationship of thyroid hormone status with myocardial function in stress cardiomyopathy.

Abstract

OBJECTIVE:

This study aimed to investigate thyroid hormone (TH) status and its relationship with myocardial function as well as clinical and biochemical parameters in stress cardiomyopathy (CMP).

METHODS:

Forty-five patients with stress CMP (the patient group), 31 patients without stress CMP (the control II group), and 58 healthy subjects (the control I group) were included. Sick euthyroid syndrome (SES) was defined as low total triiodothyronine (T(3)) with normal TSH levels.

RESULTS:

In the patient group at admission, prevalence of SES was 62.2%. Compared with the control I group, the patient group had a decrease in left ventricular ejection fraction (LVEF) and systolic blood pressure (BP) and an increase in troponin-I, CK-MB, and B-type natriuretic peptide (BNP) levels. Total T(3) levels were reduced, and anti-thyroid peroxidase antibody (anti-TPO Ab) positivity, C-reactive protein (CRP) and cortisol levels were elevated. Total T(3) levels were associated with acute physiology and chronic health evaluation II (APACHE II) score, LVEF, systolic BP, and cortisol levels in multivariate analysis. In the control II group, total T(3) levels were not associated with any variables. In the SES (n=28) and myocardial dysfunction (MDys, n=27) subgroups, increased APACHE II score and BNP levels as well as decreased LVEF and systolic BP were significant. Total T(3) levels were reduced, and CRP, cortisol and catecholamines levels were elevated. In the MDys subgroup, anti-TPO Ab positivity and titer were increased.

CONCLUSION:

These results suggest that total T(3) levels may be associated with myocardial contractility, clinical severity, and cortisol levels. Thyroid autoimmunity may influence myocardial contractility in stress CMP.

• Authors: Seong Jin Lee, Jun Goo Kang, Ohk Hyun Ryu, Chul Sik Kim, Sung-Hee Ihm, Moon Gi Choi, Hyung Joon Yoo, Kyung Soon Hong
• Journal: European journal of endocrinology (Eur J Endocrinol) Vol. 160 Issue 5 Pg. 799-806 (May 2009) ISSN: 1479-683X [Electronic] England
• PMID: 19221174 (Publication Type: Journal Article)

Chemical References

• Thyroid Hormones
• Thyrotropin

Topics

• Aged
• Blood Pressure
• Case-Control Studies
• Euthyroid Sick Syndromes (blood, epidemiology, physiopathology)
• Female
• Heart (physiology)
• Humans
• Male
• Middle Aged
• Prevalence
• Recovery of Function (physiology)
• Stress Disorders, Traumatic (blood, complications, epidemiology, physiopathology)
• Takotsubo Cardiomyopathy (blood, epidemiology, etiology, physiopathology)
• Thyroid Hormones (blood)
• Thyrotropin (blood)
• Ventricular Function, Left (physiology)