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Olanzapine in cocaine dependence: a double-blind, placebo-controlled trial.

Abstract
Preclinical and uncontrolled human studies have suggested the possible efficacy of second-generation antipsychotics, particularly olanzapine, in treating cocaine dependence. We conducted a randomized, double-blind, placebo-controlled trial in which 48 cocaine-dependent subjects received olanzapine or identical-appearing placebo for 16 weeks. The primary outcome measure was the proportion of cocaine-negative weekly urine screens during treatment. Secondary measures included scores on a Craving Questionnaire, Addiction Severity Index subscales, and extrapyramidal symptom scales. Olanzapine and placebo did not differ on any outcome measure. Both olanzapine and placebo subjects frequently reported side effects, but no unexpected ones. We conclude that olanzapine appears ineffective for cocaine dependence.
AuthorsJoseph D Hamilton, Quang X Nguyen, Robert M Gerber, Nancy B Rubio
JournalThe American journal on addictions (Am J Addict) 2009 Jan-Feb Vol. 18 Issue 1 Pg. 48-52 ISSN: 1521-0391 [Electronic] England
PMID19219665 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Antipsychotic Agents
  • Placebos
  • Benzodiazepines
  • Cocaine
  • Olanzapine
Topics
  • Adult
  • Antipsychotic Agents (adverse effects, therapeutic use)
  • Benzodiazepines (adverse effects, therapeutic use)
  • Cocaine (urine)
  • Cocaine-Related Disorders (drug therapy)
  • Double-Blind Method
  • Humans
  • Male
  • Middle Aged
  • Olanzapine
  • Placebos
  • Psychiatric Status Rating Scales
  • Treatment Outcome
  • Veterans

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