Pancreatic insulinoma co-existing with gastric GIST in the absence of neurofibromatosis-1.

Abstract

BACKGROUND:

Gastrointestinal stromal tumours (GIST) frequently occur in patients with neurofibromatosis type 1 (NF-1). It has been reported that GIST may co-exist with pancreatic endocrine tumors but this has only been in association with NF-1.

CASE PRESENTATION:

A 76 year old woman presented with a 12 month history of hypoglycaemia symptoms. Abdominal CT scan demonstrated a 13 mm insulinoma localized in the tail of her pancreas. She was commenced on diazoxide and later underwent surgery for enucleation of insulinoma when a small (< 1 cm) incidental tumour was discovered on her stomach wall which was identified as GIST.

CONCLUSION:

This is the first case report of a pancreatic insulinoma co-existing with a GIST in a patient without NF-1. In addition, we make the first report of rapidly growing cystic GIST recurrence following resection of a primary GIST tumour.

• Authors: Edward Alabraba, Simon Bramhall, Brendan O'Sullivan, Brinder Mahon, Philippe Taniere
• Journal: World journal of surgical oncology (World J Surg Oncol) Vol. 7 Pg. 18 (Feb 13 2009) ISSN: 1477-7819 [Electronic] England
• PMID: 19216788 (Publication Type: Case Reports, Journal Article)

Topics

• Aged
• Diagnosis, Differential
• Female
• Gastrointestinal Stromal Tumors (complications, pathology, surgery)
• Humans
• Hypoglycemia (diagnosis)
• Insulinoma (complications, pathology, surgery)
• Neurofibromatosis 1
• Pancreatic Neoplasms (complications, pathology, surgery)
• Stomach Neoplasms (complications, pathology, surgery)
• Tomography, X-Ray Computed