Abstract | BACKGROUND: Compared with other statins, rosuvastatin has a relatively long half-life, which may allow for the administration of this medication on an alternate day basis. OBJECTIVE: To compare the efficacy of administering rosuvastatin on a daily basis versus on an alternate day basis for the treatment of dyslipidemia. METHODS: RESULTS:
LDL-C decreased by 48.5% versus 40.9% with daily and alternate day dosing, respectively. This represented an additional absolute reduction of LDL-C of 7.6% (95% CI 1.8% to 13.4%, P=0.012) with the daily dosing regimen. Both dosing regimens provided similar improvements in high-density lipoprotein cholesterol and triglycerides. CONCLUSIONS: Compared with alternate day dosing, daily dosing of rosuvastatin provides a statistically significant advantage in LDL-C reduction. However, the alternate day regimen may be a viable option for those patients in whom cost is a limitation to compliance.
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Authors | Daisy Dulay, Stephen A LaHaye, Karen A Lahey, Andrew G Day |
Journal | The Canadian journal of cardiology
(Can J Cardiol)
Vol. 25
Issue 2
Pg. e28-31
(Feb 2009)
ISSN: 1916-7075 [Electronic] England |
PMID | 19214297
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, HDL
- Cholesterol, LDL
- Fluorobenzenes
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Pyrimidines
- Sulfonamides
- Triglycerides
- Rosuvastatin Calcium
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Cholesterol, HDL
(drug effects)
- Cholesterol, LDL
(drug effects)
- Confidence Intervals
- Cross-Over Studies
- Drug Administration Schedule
- Female
- Fluorobenzenes
(administration & dosage, pharmacokinetics)
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(administration & dosage, pharmacokinetics)
- Hypercholesterolemia
(drug therapy)
- Male
- Middle Aged
- Patient Compliance
- Pyrimidines
(administration & dosage, pharmacokinetics)
- Rosuvastatin Calcium
- Sulfonamides
(administration & dosage, pharmacokinetics)
- Triglycerides
(blood)
- Young Adult
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