Abstract | INTRODUCTION: METHODS: In this randomized, single-blind clinical trial we compared the efficacy of parenteral vitamin B(12) and nortriptyline, for symptomatic improvement of pain, paresthesia, burning, freezing, stabbing and electrical sensation. Changes in nerve conduction parameters of amplitude, duration and latency were also compared. RESULTS: One hundred patients (50 in each group) completed the study. After treatment, the pain score based on a visual analogue scale decreased 3.66 units in the vitamin B(12) group and 0.84 units in the nortriptyline group (P <0.001). Similarly, the paresthesia score decreased 2.98 units versus 1.06 units (P <0.001). The decrements of tingling sensation were 3.48 units versus 1.02 units (P <0.001). Changes in vibration, position, pinprick and nerve conduction parameters were not significant in two groups. CONCLUSION:
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Authors | Afsaneh Talaei, Mansour Siavash, Hamid Majidi, Ali Chehrei |
Journal | International journal of food sciences and nutrition
(Int J Food Sci Nutr)
Vol. 60 Suppl 5
Pg. 71-6
( 2009)
ISSN: 1465-3478 [Electronic] England |
PMID | 19212856
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Non-Narcotic
- Anticonvulsants
- Antidepressive Agents, Tricyclic
- Blood Glucose
- Glycated Hemoglobin A
- Lipids
- hemoglobin A1c protein, human
- Nortriptyline
- Vitamin B 12
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Topics |
- Adolescent
- Adult
- Analgesics, Non-Narcotic
(administration & dosage, adverse effects, therapeutic use)
- Anticonvulsants
(adverse effects, therapeutic use)
- Antidepressive Agents, Tricyclic
(adverse effects, therapeutic use)
- Blood Glucose
(analysis)
- Diabetic Neuropathies
(drug therapy, physiopathology)
- Female
- Glycated Hemoglobin
(analysis)
- Humans
- Injections, Intramuscular
- Lipids
(blood)
- Male
- Middle Aged
- Neural Conduction
(drug effects)
- Neuralgia
(drug therapy)
- Neurons
(drug effects)
- Nortriptyline
(adverse effects, therapeutic use)
- Pain Measurement
- Paresthesia
(drug therapy)
- Surveys and Questionnaires
- Time Factors
- Vitamin B 12
(administration & dosage, adverse effects, therapeutic use)
- Young Adult
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