[Membranous glomerulonephritis probably related to bucillamine therapy in two patients with rheumatoid arthritis].

Abstract

We describe here two patients with rheumatoid arthritis who developed nephrotic syndrome after administration of bucillamine, a novel antirheumatic drug developed in Japan. The nephrotic syndrome occurred after six months' and five months' treatment of bucillamine, respectively. The renal biopsy showed early phase of membranous glomerulonephritis (stage 1) in both patients. The first patient was a 64-year-old man who had received gold therapy for two years, and penicillamine therapy for eight months before bucillamine therapy. The nephrotic syndrome occurred after one year's cessation of the gold therapy and six months' cessation of the penicillamine therapy. The other patient, 57-year-old woman, had no history of gold or penicillamine therapy. Our experience suggests that membranous glomerulonephritis might occur in relation to bucillamine therapy.

• Authors: N Baba, T Nomura, T Sakemi, M Uchida, T Watanabe
• Journal: Nihon Jinzo Gakkai shi (Nihon Jinzo Gakkai Shi) Vol. 33 Issue 6 Pg. 629-34 (Jun 1991) ISSN: 0385-2385 [Print] Japan
• PMID: 1920943 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Complement C3
• Immunoglobulin G
• Cysteine
• bucillamine

Topics

• Anti-Inflammatory Agents
• Arthritis, Rheumatoid (drug therapy)
• Complement C3 (metabolism)
• Cysteine (adverse effects, analogs & derivatives)
• Female
• Glomerulonephritis, Membranous (chemically induced, pathology)
• Humans
• Immunoglobulin G (metabolism)
• Kidney (immunology, pathology)
• Male
• Middle Aged