Abstract | AIM: The aim of this study was to assess the usefulness of (153)samarium-ethylene-diamino-tetramethylene phosphonic acid ((153) Sm-EDTMP, a beta and gamma emitter) treatment in the palliation of painful bone metastases from breast cancer. PATIENTS AND METHODS: 43 women (aged 41-79, mean 60 years) with bone-disseminated breast cancer and bone pain refractory to opioid analgesics received (153)Sm-EDTMP. Karnofsky performance status, pain score (numeric rating scale), analgesic score (World Health Organisation) and blood count were evaluated before treatment and 1 and 3 months after the treatment. RESULTS: Significant pain relief was observed in 51 and 42% of the patients, mild relief in 30 and 30%, and no effect in 19 and 28% of the patients 1 and 3 months after administration, respectively. Mild and transient bone marrow suppression was observed as a side effect of (153)Sm-EDTMP treatment. None of the patients showed grade 4 haematological toxicity and only 1 patient showed grade 3 (National Cancer Institute common toxicity criteria). The majority of patients had grade 1 or 2 haematological toxicity. CONCLUSION: (153)Sm-EDTMP treatment is effective and safe in bone pain palliation in breast cancer. 3 months after administering (153)Sm-EDTMP, pain relief to varying degrees was observed in 72% of patients.The haematological toxicity after (153)Sm-EDTMP treatment was mild and transient.
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Authors | Jiri Dolezal |
Journal | Onkologie
(Onkologie)
Vol. 32
Issue 1-2
Pg. 35-9
(Feb 2009)
ISSN: 1423-0240 [Electronic] Switzerland |
PMID | 19209017
(Publication Type: Clinical Trial, Journal Article)
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Copyright | Copyright (c) 2009 S. Karger AG, Basel. |
Chemical References |
- Organometallic Compounds
- Organophosphorus Compounds
- Radiopharmaceuticals
- samarium Sm-153 lexidronam
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Topics |
- Adult
- Aged
- Bone Marrow Diseases
(diagnosis, etiology)
- Bone Neoplasms
(complications, radiotherapy, secondary)
- Breast Neoplasms
(radiotherapy)
- Female
- Humans
- Middle Aged
- Organometallic Compounds
(adverse effects, therapeutic use)
- Organophosphorus Compounds
(adverse effects, therapeutic use)
- Pain
(etiology, prevention & control)
- Pain Measurement
(radiation effects)
- Radiation Injuries
(diagnosis, etiology)
- Radiopharmaceuticals
(adverse effects, therapeutic use)
- Treatment Outcome
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