Electrophysiological effects of neurotensin on globus pallidus neurons of 6-hydroxydopamine-lesioned rats.

Abstract	The globus pallidus is a nucleus in the indirect pathway of the basal ganglia circuits. Neurotensin has been reported to play an important role in the central nervous system. Functional study revealed that systemic administration of neurotensin produced antiparkinsonian effects. The aim of the present study was to investigate the effects of neurotensin on the firing rate of globus pallidus neurons in 6-hydroxydopamine-lesioned parkinsonian rats. Micropressure ejection of neurotensin increased the spontaneous firing rate of globus pallidus neurons on both lesioned and unlesioned sides. Furthermore, the neurotensin-induced increase in firing rate on the unlesioned side (95.9%) was stronger than that on the lesioned side (37.3%). The neurotensin receptor antagonist, SR48692, prevented neurotensin-induced increase in firing rate. Based on the excitatory effects of neurotensin in globus pallidus of parkinsonian rats, we hypothesize that the pallidal neurotensinergic system may be involved in its possible therapy in Parkinson's disease.
Authors	Yan Xue, Bo Bai, Wing-Ho Yung, Lei Chen
Journal	Neuro-Signals (Neurosignals) Vol. 17 Issue 2 Pg. 153-61 ( 2009) ISSN: 1424-8638 [Electronic] Switzerland
PMID	19202346 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	2009 S. Karger AG, Basel.
Chemical References	Antiparkinson Agents Central Nervous System Agents Pyrazoles Quinolines SR 48692 Neurotensin Oxidopamine Tyrosine 3-Monooxygenase
Topics	Action Potentials (drug effects) Animals Antiparkinson Agents (administration & dosage) Central Nervous System Agents (pharmacology) Globus Pallidus (drug effects, physiology) Immunohistochemistry Male Microelectrodes Motor Activity Neurons (drug effects, physiology) Neurotensin (administration & dosage, antagonists & inhibitors) Oxidopamine Parkinson Disease, Secondary (chemically induced, drug therapy) Photomicrography Pyrazoles (pharmacology) Quinolines (pharmacology) Rats Rats, Wistar Substantia Nigra (drug effects, metabolism) Tyrosine 3-Monooxygenase (metabolism)

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