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Primary cutaneous CD30+ anaplastic large cell lymphoma in a heart transplant patient: case report and literature review.

Abstract
Solid organ transplant recipients are at risk of developing a wide range of viral-associated malignancies, including skin tumours and lymphoproliferative disorders. The risk of a post-transplant lymphoproliferative disorder is 28-49 times the risk of a lymphoproliferative disorder in the normal population. Most cases are of B-cell phenotype and are associated with Epstein-Barr virus infection. Post-transplant lymphoproliferative disorders presenting clinically in the skin are rare and usually of B-cell phenotype. Only rare cases of cutaneous T-cell post-transplant lymphoproliferative disorder have been reported previously, mostly mycosis fungoides type. We describe here a rare primary cutaneous T-cell lymphoma CD30+ arising in a heart transplant patient who had a nodule on the right leg, several years after heart transplantation. The morphology and immunohistochemical findings were consistent with a CD30+ anaplastic large cell lymphoma with a T-cell phenotype. Excisional biopsy and radiotherapy of the affected area were performed. In this patient, the presence of a solitary lesion and the lack of systemic involvement represented the main factors taken into account in choosing the therapy and the patient was therefore treated using a non-aggressive approach, although with systemic immunosuppression. In conclusion, the diagnosis of a CD30+ anaplastic large cell lymphoma in transplant recipients does not imply aggressive clinical behaviour by the lymphoma.
AuthorsAnna Belloni-Fortina, Maria Cristina Montesco, Stefano Piaserico, Matteo Bordignon, Francesco Tona, Giuseppe Feltrin, Mauro Alaibac
JournalActa dermato-venereologica (Acta Derm Venereol) Vol. 89 Issue 1 Pg. 74-7 ( 2009) ISSN: 0001-5555 [Print] Sweden
PMID19197546 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Ki-1 Antigen
Topics
  • Aged
  • Heart Transplantation
  • Humans
  • Ki-1 Antigen (analysis)
  • Lymphoma, T-Cell, Cutaneous (etiology, pathology)
  • Male
  • Postoperative Complications
  • Skin Neoplasms (etiology, pathology)

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