Abstract | PURPOSE: METHODS: RESULTS: Baseline HRV parameters were blunted in patients with diabetes mellitus according to the controls [standard deviation of all NN intervals (SDNN, ms): 106.3+/-29.9 vs. 148.8+/-36.5, P=.001; power spectrum of the high-frequency band (HF, ms(2)): 133.6+/-98.3 to 231.4+/-197.6, P=.02; power spectrum of the low-frequency band (LF, ms(2)): 341.8+/-247.8 to 511.5+/-409.4, P=.048; LF/HF ratio: 3.3+/-2.4 to 2.6+/-1.5, P=.33]. After 3 months of treatment with gabapentin, some HRV parameters showed some improvement. SDNN (106.2+/-29.8 to 119.4 +/- 25, P=.016) and HF (133.6+/-98.3 to 167.6+/-118.3, P=.021) increased significantly. LF/HF ratio decreased (from 3.3+/-2.4 to 2.3+/-1.9, P=.039) and LF remained unchanged (341.8+/-247.8 to 352.3+/-228.9, P=.88). CONCLUSIONS: Therapeutic doses of gabapentin not only alleviate neuropathic symptoms but also improve cardiac autonomic function in diabetic patients with peripheral neuropathy.
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Authors | Necip Ermis, Hakan Gullu, Mustafa Caliskan, Aydan Unsal, Mustafa Kulaksizoglu, Haldun Muderrisoglu |
Journal | Journal of diabetes and its complications
(J Diabetes Complications)
2010 Jul-Aug
Vol. 24
Issue 4
Pg. 229-33
ISSN: 1873-460X [Electronic] United States |
PMID | 19195912
(Publication Type: Controlled Clinical Trial, Journal Article)
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Copyright | Copyright 2010 Elsevier Inc. All rights reserved. |
Chemical References |
- Amines
- Cyclohexanecarboxylic Acids
- Excitatory Amino Acid Antagonists
- gamma-Aminobutyric Acid
- Gabapentin
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Topics |
- Adult
- Aged
- Amines
(administration & dosage, pharmacology, therapeutic use)
- Arrhythmias, Cardiac
(drug therapy, etiology)
- Autonomic Nervous System
(drug effects, physiopathology)
- Autonomic Nervous System Diseases
(drug therapy, etiology, physiopathology)
- Cyclohexanecarboxylic Acids
(administration & dosage, pharmacology, therapeutic use)
- Diabetic Neuropathies
(complications, drug therapy, physiopathology)
- Dose-Response Relationship, Drug
- Electrocardiography
- Excitatory Amino Acid Antagonists
(administration & dosage, pharmacology, therapeutic use)
- Female
- Gabapentin
- Heart Rate
(drug effects, physiology)
- Humans
- Male
- Middle Aged
- Peripheral Nervous System Diseases
(drug therapy, etiology, physiopathology)
- gamma-Aminobutyric Acid
(administration & dosage, pharmacology, therapeutic use)
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