[Treatment of steroid-resistant idiopathic nephrotic syndrome].

Abstract

Idiopathic nephrotic syndrome (INS) is the most frequent glomerular nephropathy in children. The response to corticoids distinguishes steroid-sensitive nephrotic syndrome (SSINS), by far the most frequent (90% of cases), from steroid-resistant nephrotic syndrome (SRINS). The steroid resistance of nephrotic syndrome is defined by the absence of remission after a full dose of oral corticosteroid therapy for 1 month followed by 3 pulses of intravenous methylprednisolone. Actually, INS constitutes a heterogeneous nosologic entity. Currently, within the SRINS, there are 2 forms that vary greatly in their physiopathology and prognostics: immunologic or sporadic forms, which can be improved by immunosuppressive agents and the genetic or familial forms, which do not respond to any immunosuppressive therapy and usually evolve to end-stage renal insufficiency. In these genetic forms, renal transplantation is the only therapeutic alternative. The aim of this article is to review treatment of SRINS and to propose a management strategy.

• Authors: J Chemli, A Harbi
• Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie (Arch Pediatr) Vol. 16 Issue 3 Pg. 260-8 (Mar 2009) ISSN: 0929-693X [Print] France
• Vernacular Title: Traitement du syndrome néphrotique idiopathique corticorésistant.
• PMID: 19195856 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Adrenal Cortex Hormones
• Enzyme Inhibitors
• Immunosuppressive Agents

Topics

• Adrenal Cortex Hormones (administration & dosage, adverse effects)
• Drug Resistance
• Enzyme Inhibitors (therapeutic use)
• Humans
• Immunosorbent Techniques
• Immunosuppressive Agents (therapeutic use)
• Kidney Transplantation
• Nephrotic Syndrome (therapy)
• Plasmapheresis