Efficacy of cryotherapy versus intralesional meglumine antimoniate (glucantime) for treatment of cutaneous leishmaniasis in children.

We compared intralesional glucantine and cryotherapy for treatment of children with cutaneous leishmaniasis in Iran. We observed that cryotherapy is an effective treatment for cutaneous leishmaniasis in children. No serious post-treatment side effects were observed in either group. At six months of follow-up, no recurrence of disease was observed in cured patients in either group. Because of its simplicity, lower cost, low rate of serious complications, and greater tolerability, cryotherapy should be recommended as an appropriate alternative treatment for leishmaniasis in children.
AuthorsPouran Layegh, Fakhrozaman Pezeshkpoor, Amir Hossein Soruri, Parisa Naviafar, Toktam Moghiman
JournalThe American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 80 Issue 2 Pg. 172-5 (Feb 2009) ISSN: 1476-1645 [Electronic] United States
PMID19190206 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Antiprotozoal Agents
  • Organometallic Compounds
  • Meglumine
  • meglumine antimoniate
  • Antiprotozoal Agents (therapeutic use)
  • Child
  • Child, Preschool
  • Cryotherapy
  • Female
  • Humans
  • Injections, Intralesional
  • Iran
  • Leishmaniasis, Cutaneous (drug therapy, parasitology, therapy)
  • Male
  • Meglumine (therapeutic use)
  • Organometallic Compounds (therapeutic use)
  • Treatment Outcome

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