Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.

Abstract

A new series of 6 dimeric trioxane sulfones has been prepared from the natural trioxane artemisinin in five or six chemical steps. One of these thermally and hydrolytically stable new chemical entities (4c) completely cured malaria-infected mice via a single oral dose of 144 mg/kg. At a much lower single oral dose of only 54 mg/kg combined with 13 mg/kg of mefloquine hydrochloride, this trioxane dimer 4c as well as its parent trioxane dimer 4b also completely cured malaria-infected mice. Both dimers 4c and 4b were potently and selectively cytotoxic toward five cancer cell lines.

• Authors: Andrew S Rosenthal, Xiaochun Chen, Jun O Liu, Diana C West, Paul J Hergenrother, Theresa A Shapiro, Gary H Posner
• Journal: Journal of medicinal chemistry (J Med Chem) Vol. 52 Issue 4 Pg. 1198-203 (Feb 26 2009) ISSN: 1520-4804 [Electronic] United States
• PMID: 19186946 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Antimalarials
• Antineoplastic Agents
• Artemisinins
• Sulfones
• artemisinin
• Mefloquine

Topics

• Administration, Oral
• Animals
• Antimalarials (administration & dosage, pharmacology)
• Antineoplastic Agents (pharmacology)
• Artemisinins
• Cell Line, Tumor
• Drug Screening Assays, Antitumor
• Drug Stability
• Drug Therapy, Combination
• Humans
• Malaria (drug therapy)
• Mefloquine (administration & dosage, pharmacology)
• Mice
• Sulfones (administration & dosage, pharmacology)