Abstract | BACKGROUND: METHODS: The study included nine groups; an uncontaminated and a contaminated untreated control groups, and seven contaminated groups that received HBO or systemic antibiotics with linezolid, vancomycin, or teicoplanin, or a combination therapy consisting of one of these antibiotics and HBO. There were six adult male Wistar rats in each group. Contaminated groups were inoculated with 0.5 mL 10(8) CFU/mL methicillin resistant Staphylococcus aureus in the mediastinal and in the sternal layers. The antibiotic treatment continued 7 d. Twelve hours later at the end of the treatment, the rats were sacrificed, a sternotomy was performed for each rat and tissue samples from the upper ends of the sternum were aseptically obtained and evaluated microbiologically. RESULTS: There was no difference between the therapeutic efficacy of linezolid, teicoplanin, or vancomycin (P>0.05). When the groups were analyzed separately, treatment with a combination of HBO and antibiotic therapy reduced the bacterial count in comparison with HBO or antibiotic treatment alone (P<0.05). The combination of teicoplanin or vancomycin and HBO, respectively, was not more effective in reducing the bacterial count in comparison with the combination of linezolid and HBO (P>0.05). CONCLUSIONS:
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Authors | Vedat Turhan, Suzan Sacar, Gunalp Uzun, Mustafa Sacar, Senol Yildiz, Nurgul Ceran, Rauf Gorur, Oral Oncul |
Journal | The Journal of surgical research
(J Surg Res)
Vol. 155
Issue 1
Pg. 111-5
(Jul 2009)
ISSN: 1095-8673 [Electronic] United States |
PMID | 19181335
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Acetamides
- Anti-Infective Agents
- Oxazolidinones
- Teicoplanin
- Vancomycin
- Linezolid
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Topics |
- Acetamides
(therapeutic use)
- Animals
- Anti-Infective Agents
(therapeutic use)
- Combined Modality Therapy
- Hyperbaric Oxygenation
- Linezolid
- Male
- Mediastinitis
(microbiology, therapy)
- Methicillin-Resistant Staphylococcus aureus
- Oxazolidinones
(therapeutic use)
- Rats
- Rats, Wistar
- Staphylococcal Infections
(therapy)
- Teicoplanin
(therapeutic use)
- Vancomycin
(therapeutic use)
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