Granulocyte transfusion in children.

Abstract

We describe a single institution experience with the use of granulocyte transfusion in children. This is a retrospective analysis of 45 collections of granulocyte units obtained by apheresis after priming with dexamethasone, infused into 17 children with severe neutropenic infections. Ten children survived the acute infection. Granulocyte transfusion is a useful adjunct to antimicrobials and growth factors in post chemotherapy neutropenic sepsis and is highly effective in children with chronic granulomatous disease and life threatening infections.

• Authors: Revathi Raj, Shrishu R Kamath, Suchitra Ranjit, Nirmal Shankar, V Lakshmanan
• Journal: Indian pediatrics (Indian Pediatr) Vol. 46 Issue 6 Pg. 516-8 (Jun 2009) ISSN: 0019-6061 [Print] India
• PMID: 19179734 (Publication Type: Journal Article)

Topics

• Adolescent
• Child
• Child, Preschool
• Female
• Granulocytes
• Humans
• India (epidemiology)
• Infant
• Leukocyte Transfusion (methods, mortality)
• Male
• Neutropenia (etiology, mortality, therapy)
• Retrospective Studies
• Sepsis (blood, complications, mortality)
• Treatment Outcome