Abstract |
Three groups of healthy dogs with low antibody titers to Bordetella bronchiseptica (Bb), canine parainfluenza virus ( CPI), and canine adenovirus type 2 (CAV-2) were used in this study. One group was vaccinated with a single dose of monovalent attenuated Bb vaccine and one group with a trivalent vaccine containing attenuated Bb, CPI, and CAV-2; dogs were vaccinated intranasally with a single dose of the respective vaccines. The third group served as unvaccinated controls. All vaccinated dogs subsequently developed serum antibody titers to Bb that persisted for at least 1 year. Following Bb challenge 1 year after vaccination, all vaccinated dogs, regardless of group, showed significantly fewer clinical signs and shed significantly fewer challenge organisms than unvaccinated controls. These results demonstrate that intranasal administration of a single dose of monovalent attenuated Bb vaccine or trivalent vaccine containing attenuated Bb, CPI, and CAV-2 provides 1 year of protection against Bb.
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Authors | Craig Lehar, Huchappa Jayappa, Jason Erskine, Alicia Brown, Diane Sweeney, Terri Wassmoen |
Journal | Veterinary therapeutics : research in applied veterinary medicine
(Vet Ther)
Vol. 9
Issue 4
Pg. 257-62
( 2008)
ISSN: 1528-3593 [Print] United States |
PMID | 19177330
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Bacterial
- Antibodies, Viral
- Bacterial Vaccines
- Parainfluenza Vaccines
- Vaccines, Attenuated
- Viral Vaccines
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Topics |
- Adenoviridae Infections
(prevention & control, veterinary)
- Adenoviruses, Canine
(immunology)
- Administration, Intranasal
- Animals
- Animals, Newborn
- Antibodies, Bacterial
(blood)
- Antibodies, Viral
(blood)
- Bacterial Vaccines
(administration & dosage)
- Bordetella Infections
(prevention & control, veterinary)
- Bordetella bronchiseptica
(immunology)
- Dog Diseases
(prevention & control)
- Dogs
- Female
- Male
- Parainfluenza Vaccines
(administration & dosage)
- Parainfluenza Virus 2, Human
(immunology)
- Random Allocation
- Rubulavirus Infections
(prevention & control, veterinary)
- Vaccines, Attenuated
- Viral Vaccines
(administration & dosage)
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