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Cerebrospinal fluid cytokine levels in migraine, tension-type headache and cervicogenic headache.

Abstract
Cytokines have been measured in cerebrospinal fluid (CSF) from headache patients [infrequent episodic tension-type headache (TTH) and migraine with or without aura, all during attack, and cervicogenic headache] and compared with levels in pain-free individuals. Both proinflammatory [interleukin (IL)-1beta, tumour necrosis factor-alpha and monocyte chemoattractant protein-1 (MCP-1)] and anti-inflammatory cytokines [IL-1 receptor antagonist (IL-1ra), IL-4, IL-10 and transforming growth factor-beta1 (TGF-beta1)] were included. There were significant group differences in IL-1ra, TGF-beta1 and MCP-1 in episodic TTH and migraine compared with controls, and a significant difference in MCP-1 between cervicogenic headache and migraine with aura. Intrathecal MCP-1 correlated with IL-1ra, IL-10 and TGF-beta1 in episodic TTH, and MCP-1 with IL-10 in migraine with aura. Cytokine increases were modest compared with those often accompanying serious neurological conditions, and may represent a mild response to pain. We believe this to be the first comparative study of CSF cytokine levels in connection with headache.
AuthorsS H Bø, E M Davidsen, P Gulbrandsen, E Dietrichs, G Bovim, L J Stovner, L R White
JournalCephalalgia : an international journal of headache (Cephalalgia) Vol. 29 Issue 3 Pg. 365-72 (Mar 2009) ISSN: 1468-2982 [Electronic] England
PMID19175774 (Publication Type: Journal Article)
Chemical References
  • Chemokine CCL2
  • Cytokines
  • Receptors, Interleukin-1
  • Transforming Growth Factor beta1
  • Interleukin-10
Topics
  • Adolescent
  • Adult
  • Aged
  • Chemokine CCL2 (cerebrospinal fluid)
  • Cytokines (cerebrospinal fluid)
  • Female
  • Humans
  • Interleukin-10 (cerebrospinal fluid)
  • Male
  • Middle Aged
  • Migraine Disorders (cerebrospinal fluid)
  • Post-Traumatic Headache (cerebrospinal fluid)
  • Receptors, Interleukin-1 (analysis)
  • Tension-Type Headache (cerebrospinal fluid)
  • Transforming Growth Factor beta1 (cerebrospinal fluid)

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