Abstract |
Cytokines have been measured in cerebrospinal fluid (CSF) from headache patients [infrequent episodic tension-type headache (TTH) and migraine with or without aura, all during attack, and cervicogenic headache] and compared with levels in pain-free individuals. Both proinflammatory [ interleukin (IL)-1beta, tumour necrosis factor-alpha and monocyte chemoattractant protein-1 (MCP-1)] and anti-inflammatory cytokines [ IL-1 receptor antagonist (IL-1ra), IL-4, IL-10 and transforming growth factor-beta1 (TGF-beta1)] were included. There were significant group differences in IL-1ra, TGF-beta1 and MCP-1 in episodic TTH and migraine compared with controls, and a significant difference in MCP-1 between cervicogenic headache and migraine with aura. Intrathecal MCP-1 correlated with IL-1ra, IL-10 and TGF-beta1 in episodic TTH, and MCP-1 with IL-10 in migraine with aura. Cytokine increases were modest compared with those often accompanying serious neurological conditions, and may represent a mild response to pain. We believe this to be the first comparative study of CSF cytokine levels in connection with headache.
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Authors | S H Bø, E M Davidsen, P Gulbrandsen, E Dietrichs, G Bovim, L J Stovner, L R White |
Journal | Cephalalgia : an international journal of headache
(Cephalalgia)
Vol. 29
Issue 3
Pg. 365-72
(Mar 2009)
ISSN: 1468-2982 [Electronic] England |
PMID | 19175774
(Publication Type: Journal Article)
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Chemical References |
- Chemokine CCL2
- Cytokines
- Receptors, Interleukin-1
- Transforming Growth Factor beta1
- Interleukin-10
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Topics |
- Adolescent
- Adult
- Aged
- Chemokine CCL2
(cerebrospinal fluid)
- Cytokines
(cerebrospinal fluid)
- Female
- Humans
- Interleukin-10
(cerebrospinal fluid)
- Male
- Middle Aged
- Migraine Disorders
(cerebrospinal fluid)
- Post-Traumatic Headache
(cerebrospinal fluid)
- Receptors, Interleukin-1
(analysis)
- Tension-Type Headache
(cerebrospinal fluid)
- Transforming Growth Factor beta1
(cerebrospinal fluid)
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