Successful treatment of refractory Langerhans cell histiocytosis with pulmonary aspergillosis by reduced-intensity conditioning cord blood transplantation.

Abstract

The prognosis of multisystem LCH in children with risk organ involvement is extremely poor when they fail to respond to conventional chemotherapy. In such patients, allogeneic SCT may produce complete and sustained remission; however, high-dose myeloablative regimens are frequently associated with treatment-related morbidity and mortality. More recently, allogeneic SCT following an RIC regimen has been performed as an alternative salvage approach. We describe a nine-month-old boy with refractory multisystem LCH with pulmonary aspergillosis who was successfully treated with reduced-intensity cord blood transplantation.

• Authors: Naoki Hatakeyama, Tsukasa Hori, Masaki Yamamoto, Natsuko Inazawa, Yoko Hirako, Hiroyuki Tsutsumi, Nobuhiro Suzuki
• Journal: Pediatric transplantation (Pediatr Transplant) Vol. 14 Issue 3 Pg. E4-10 (May 2010) ISSN: 1399-3046 [Electronic] Denmark
• PMID: 19175514 (Publication Type: Case Reports, Journal Article)

Topics

• Cord Blood Stem Cell Transplantation
• Disease Progression
• Histiocytosis, Langerhans-Cell (complications, therapy)
• Humans
• Infant
• Male
• Pulmonary Aspergillosis (complications, therapy)
• Transplantation Conditioning (methods)