[Interaction between an insertion/deletion polymorphism in pepsinogen C and Helicobacter pylori infection in the development of gastric cancer].

Abstract

OBJECTIVE:

This study was designed to investigate the interaction between pepsinogen C(PGC) insertion/deletion polymorphism and Helicobacter pylori(Hp) infection, together with its different subtype strains, in the development of gastric cancer (GC).

METHODS:

PGC Genotypes were determined by polymerase chain reaction (PCR) assay in 564 subjects with superficial gastritis (NOR), gastric ulcer (GU), atrophic gastritis (AG) and GC, who were frequency-matched as 1:1. Serum Hp-IgG antibodies were determined by an enzyme linked immunoadsorbent assay (ELISA). Hp genetic subtypes in 171 patients with Hp infection were determined by PCR methods.

RESULTS:

In GU, AG and GC, the OR of interaction was 8.69 (P = 0.049), 11.16 (P = 0.02), and 10.61 (P = 0.03), respectively; the interaction index of PGC homozygous allele 1 genotype and Hp infection was 5.40, 6.48 or 4.34, respectively; the attributable proportions were 0.721, 0.770 and 0.697, respectively. In AG and GC, no significant interactions were observed between PGC polymorphism and Hp genetic subtypes.

CONCLUSION:

The findings of this study suggest that PGC insertion/deletion polymorphism and Hp infection seem to present a positive interaction in the development of gastric cancer. While no interactions may be present between PGC polymorphism and Hp genetic subtypes.

• Authors: Li-Ping Sun, Ye Zhang, Yun-En Liu, Wei Chen, Yuan Yuan
• Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] (Zhonghua Zhong Liu Za Zhi) Vol. 30 Issue 9 Pg. 644-8 (Sep 2008) ISSN: 0253-3766 [Print] China
• PMID: 19173902 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Pepsinogen C

Topics

• Adult
• Aged
• Aged, 80 and over
• Alleles
• Base Sequence
• Female
• Gastritis (genetics)
• Gastritis, Atrophic (genetics)
• Genetic Predisposition to Disease (genetics)
• Genotype
• Helicobacter Infections (genetics)
• Helicobacter pylori (pathogenicity)
• Humans
• INDEL Mutation
• Male
• Middle Aged
• Molecular Sequence Data
• Pepsinogen C (genetics)
• Polymorphism, Genetic
• Stomach Neoplasms (genetics, microbiology)
• Stomach Ulcer (genetics)
• Young Adult