Abstract | UNLABELLED: MATERIAL AND METHODS: By Light's criteria in 29 cases exudates and 10 transudates was recognized. We investigated 39 patients with pleural effusion (congestive heart failure--10, parapneumonic--11, tuberculous--6, malignant--12, transudate--10). RESULTS: The mean VEGF value were significantly higher (p = 0.002) in the effusion of lung cancer patient (3958.33 pg/ml) than in the serum (1030.33 pg/ml). The mean VEGF levels were significantly higher (p = 0.004) in patient with exudates (2711.10 pg/ml) than in transudates (683 pg/ml). Based on the receiver operating characteristic (ROC) curve analysis, cut off value in differentiation of exudates and transudates was accepted at the level of 560 pg/ml (sensitivity 80% and specificity 70%). The mean VEGF levels were significantly higher (p = 0.008) in the malignant effusion (3958.33 pg/ml) than in the tuberculous effusion (1308.90 pg/ml). Based on the ROC curve analysis, cut off value in differentiation of malignant and tuberculous effusion was accepted at the level of 2000 pg/ml (sensitivity 92% and specificity 83%). The positive correlation between pleural VEGF concentrations and pleural lactate dehydrogenase (LDH) level were observed (r = 0.67, p < 0.05). CONCLUSION: We conclude that pleural effusion VEGF level could be useful in the differentiation between exudates and transudate and also between malignant and tuberculous exudates.
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Authors | Marzena Trzaska-Sobczak, Władysław Pierzchała, Grzegorz Brozek, Małgorzata Farnik |
Journal | Wiadomosci lekarskie (Warsaw, Poland : 1960)
(Wiad Lek)
Vol. 61
Issue 7-9
Pg. 190-4
( 2008)
ISSN: 0043-5147 [Print] Poland |
Vernacular Title | Ocena przydatności naczyniowo-śródbłonkowego czynnika wzrostu w diagnostyce płynu opłucnowego. |
PMID | 19172830
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Chemokines, CC
- Vascular Endothelial Growth Factor A
|
Topics |
- Aged
- Biomarkers, Tumor
(analysis)
- Chemokines, CC
(analysis)
- Enzyme-Linked Immunosorbent Assay
- Exudates and Transudates
(chemistry)
- Female
- Heart Failure
(metabolism)
- Humans
- Male
- Middle Aged
- Pleural Effusion
(chemistry)
- Pleural Effusion, Malignant
(metabolism)
- Pneumonia
(metabolism)
- ROC Curve
- Tuberculosis, Pleural
(metabolism)
- Vascular Endothelial Growth Factor A
(analysis)
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