Antiosteoporotic activity of anthraquinones from Morinda officinalis on osteoblasts and osteoclasts.

Abstract

Bioactivity-guided fractionation led to the successful isolation of antiosteoporotic components, i.e. physicion (1), rubiadin-1-methyl ether (2), 2-hydroxy-1-methoxy- anthraquinone (3), 1,2-dihydroxy-3-methylanthraquinone (4), 1,3,8-trihydroxy-2-methoxy- anthraquinone (5), 2-hydroxymethyl-3-hydroxyanthraquinone (6), 2-methoxyanthraquinone (7) and scopoletin (8) from an ethanolic extract of the roots of Morinda officinalis. Compounds 4-8 are isolated for the first time from M. officinalis. Among them, compounds 2 and 3 promoted osteoblast proliferation, while compounds 4, 5 increased osteoblast ALP activity. All of the isolated compounds inhibited osteoclast TRAP activity and bone resorption, and the inhibitory effects on osteoclastic bone resorption of compounds 1 and 5 were stronger than that of other compounds. Taken together, antiosteoporotic activity of M. officinalis and its anthraquinones suggest therapeutic potential against osteoporosis.

• Authors: Yan-Bin Wu, Cheng-Jian Zheng, Lu-Ping Qin, Lian-Na Sun, Ting Han, Lei Jiao, Qiao-Yan Zhang, Jin-Zhong Wu
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 14 Issue 1 Pg. 573-83 (Jan 23 2009) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 19169204 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anthraquinones
• Bone Density Conservation Agents
• Alkaline Phosphatase

Topics

• Alkaline Phosphatase (metabolism)
• Animals
• Anthraquinones (chemistry, pharmacology, therapeutic use)
• Bone Density Conservation Agents (chemistry, pharmacology, therapeutic use)
• Bone Resorption (drug therapy)
• Cell Proliferation (drug effects)
• Cells, Cultured
• Molecular Structure
• Morinda (chemistry)
• Osteoblasts (cytology, drug effects)
• Osteoclasts (cytology, drug effects)
• Rats
• Rats, Wistar