Cryptococcal liver abscess: a case report of successful treatment with amphotericin-B and literature review.

Abstract

Cryptococcus neoformans usually involves the central nervous system and the respiratory tract. We report a case of disseminated cryptococcosis with a liver abscess and meningoencephalitis in a patient with myelodysplastic syndrome. Computed tomography of the abdomen showed a 3-cm low-attenuated lesion in the left lobe of liver. Cultures from specimens of blood, the liver abscess, and the cerebrospinal fluid all yielded C. neoformans. The cryptococcal antigen titers for the serum and cerebral fluid were both 1:32. The patient was successfully treated with 1,335 mg of amphotericin-B followed by fluconazole. Most cryptococcal liver infections present as hepatitis, cholangitis, or microabscesses.

• Authors: Po-Yu Liu, Youngsen Yang, Zhi-Yuan Shi
• Journal: Japanese journal of infectious diseases (Jpn J Infect Dis) Vol. 62 Issue 1 Pg. 59-60 (Jan 2009) ISSN: 1344-6304 [Print] Japan
• PMID: 19168962 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Anti-Bacterial Agents
• Antifungal Agents
• Antigens, Fungal
• Amphotericin B
• Fluconazole

Topics

• Aged
• Amphotericin B (administration & dosage, therapeutic use)
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Antifungal Agents (administration & dosage, therapeutic use)
• Antigens, Fungal (analysis)
• Cryptococcosis (drug therapy, immunology)
• Cryptococcus neoformans (immunology, isolation & purification)
• Female
• Fluconazole (administration & dosage, therapeutic use)
• Humans
• Liver Abscess (diagnostic imaging, drug therapy, microbiology)
• Tomography, X-Ray Computed
• Ultrasonography