Protective effects of the complex between manganese porphyrins and catalase-poly(ethylene glycol) conjugates against hepatic ischemia/reperfusion injury in vivo.

Abstract

The complex between manganese (Mn) porphyrins and catalase-poly(ethylene glycol) (PEG) conjugates has been designed for the protective effect against hepatic ischemia/reperfusion injury in vivo. The resulting Mn-porphyrin/catalase-PEG complex with dual enzymatic activity of superoxide dismutase (SOD) and catalase enhanced the blood circulation. The spin reduction rate in the rats treated with the Mn-porphyrin/catalase-PEG complex was significantly higher than that in the untreated rats and almost equal to that in the sham group rats. Furthermore, the Mn-porphyrin/catalase-PEG complex significantly decreased the serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. These results suggest that the Mn-porphyrin/catalase-PEG complex exhibited the antioxidative activity to protect hepatic ischemia/reperfusion injury in vivo.

• Authors: Tomochika Hanawa, Shoichiro Asayama, Taiji Watanabe, Shigeru Owada, Hiroyoshi Kawakami
• Journal: Journal of controlled release : official journal of the Controlled Release Society (J Control Release) Vol. 135 Issue 1 Pg. 60-4 (Apr 02 2009) ISSN: 1873-4995 [Electronic] Netherlands
• PMID: 19162102 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Metalloporphyrins
• Reactive Oxygen Species
• Polyethylene Glycols
• tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex
• Catalase

Topics

• Animals
• Antioxidants (administration & dosage, chemistry, pharmacology)
• Catalase (administration & dosage, blood, chemistry, pharmacology)
• Drug Compounding
• Drug Stability
• Liver (blood supply, drug effects, metabolism)
• Liver Function Tests
• Male
• Metalloporphyrins (administration & dosage, blood, chemistry, pharmacology)
• Polyethylene Glycols (administration & dosage, chemistry, pharmacokinetics, pharmacology)
• Rats
• Rats, Sprague-Dawley
• Reactive Oxygen Species (metabolism)
• Reperfusion Injury (blood, metabolism, prevention & control)