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Small RNAs in transcriptional gene silencing and genome defence.

Abstract
Small RNA molecules of about 20-30 nucleotides have emerged as powerful regulators of gene expression and genome stability. Studies in fission yeast and multicellular organisms suggest that effector complexes, directed by small RNAs, target nascent chromatin-bound non-coding RNAs and recruit chromatin-modifying complexes. Interactions between small RNAs and nascent non-coding transcripts thus reveal a new mechanism for targeting chromatin-modifying complexes to specific chromosome regions and suggest possibilities for how the resultant chromatin states may be inherited during the process of chromosome duplication.
AuthorsDanesh Moazed
JournalNature (Nature) Vol. 457 Issue 7228 Pg. 413-20 (Jan 22 2009) ISSN: 1476-4687 [Electronic] England
PMID19158787 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Chromatin
  • RNA, Small Interfering
Topics
  • Animals
  • Chromatin (genetics, metabolism)
  • Epigenesis, Genetic
  • Gene Silencing (physiology)
  • Genome (genetics)
  • RNA, Small Interfering (genetics, metabolism)
  • Transcription, Genetic (genetics)

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