Abstract |
Small RNA molecules of about 20-30 nucleotides have emerged as powerful regulators of gene expression and genome stability. Studies in fission yeast and multicellular organisms suggest that effector complexes, directed by small RNAs, target nascent chromatin-bound non-coding RNAs and recruit chromatin-modifying complexes. Interactions between small RNAs and nascent non-coding transcripts thus reveal a new mechanism for targeting chromatin-modifying complexes to specific chromosome regions and suggest possibilities for how the resultant chromatin states may be inherited during the process of chromosome duplication.
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Authors | Danesh Moazed |
Journal | Nature
(Nature)
Vol. 457
Issue 7228
Pg. 413-20
(Jan 22 2009)
ISSN: 1476-4687 [Electronic] England |
PMID | 19158787
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Chromatin
- RNA, Small Interfering
|
Topics |
- Animals
- Chromatin
(genetics, metabolism)
- Epigenesis, Genetic
- Gene Silencing
(physiology)
- Genome
(genetics)
- RNA, Small Interfering
(genetics, metabolism)
- Transcription, Genetic
(genetics)
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