HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Cryoglobulinemic vasculitis with multiple digital necrosis in viral hepatitis.

Abstract
Cryoglobulinemic vasculitis (CV) associated with viral hepatitis C (VHC) is halfway between classical autoimmune disease and neoplasia. The extrahepatic manifestations of viral hepatitis C are various, their majority being due to mixed cryoglobulinemia. Patients diagnosed with viral hepatitis C often have mixed serum cryoglobulins, but only 5-10% of them will develop clinically manifest cryoglobulinemic vasculitis. CV symptomatology is most frequently obvious at skin level. The clinical manifestation characteristic of CV is purpura. Digital necrosis as the last stage of trophic disorders associated with CV has been rarely described in the literature. All CV types may be complicated by renal impairment. A 10-30% proportion of patients with VHC infection will develop glomerulonephritis. The treatment of cryobulinemic vasculitis associated with viral hepatitis C is focused on the reduction of viral load, the control of vasculitis symptoms using corticoids, plasmapheresis, immunosuppressive drugs, and the reduction of the amount of cryoglobulins acting on B lymphocytes. We present a rare case of cryoglobulinemic vasculitis with multiple digital necrosis associated with viral hepatitis C.
AuthorsA Mironiuc, Lavinia Comes, Ioana Constantinescu, Clara Mironiuc, Dana Bontea
JournalRomanian journal of internal medicine = Revue roumaine de medecine interne (Rom J Intern Med) Vol. 46 Issue 1 Pg. 91-5 ( 2008) ISSN: 1220-4749 [Print] Germany
PMID19157277 (Publication Type: Case Reports, Journal Article)
Topics
  • Adult
  • Cryoglobulinemia (pathology, virology)
  • Fingers (pathology, surgery)
  • Hepacivirus (pathogenicity)
  • Humans
  • Necrosis (pathology, surgery)
  • Toes (pathology, surgery)
  • Vasculitis (pathology, surgery, virology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: