HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Eph receptors in breast cancer: roles in tumor promotion and tumor suppression.

Abstract
Eph receptor tyrosine kinase signaling regulates cancer initiation and metastatic progression through multiple mechanisms. Studies of tumor-cell-autonomous effects of Eph receptors demonstrate their dual roles in tumor suppression and tumor promotion. In addition, Eph molecules function in the tumor microenvironment, such as in vascular endothelial cells, influencing the ability of these molecules to promote carcinoma progression and metastasis. The complex nature of Eph receptor signaling and crosstalk with other receptor tyrosine kinases presents a unique challenge and an opportunity to develop therapeutic intervention strategies for targeting breast cancer.
AuthorsDavid Vaught, Dana M Brantley-Sieders, Jin Chen
JournalBreast cancer research : BCR (Breast Cancer Res) Vol. 10 Issue 6 Pg. 217 ( 2008) ISSN: 1465-542X [Electronic] England
PMID19144211 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Review)
Chemical References
  • Antineoplastic Agents
  • Receptors, Eph Family
Topics
  • Antineoplastic Agents (therapeutic use)
  • Breast Neoplasms (drug therapy, metabolism, pathology)
  • Female
  • Humans
  • Receptors, Eph Family (antagonists & inhibitors, physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: