Effect of FX dialysers on systemic inflammation and quality of life in chronic haemodialysis patients.

Abstract

BACKGROUND:

The FX class of haemodialysers features a new class of high-flux polysulfone membrane which has been suggested to induce less inflammation.

METHODS:

This was a randomized, cross-over study performed on 33 haemodialysis patients. Patients were randomized to FX60 or HF80 dialysers for 3 months and then changed to the other dialyser. Interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) were measured at baseline, and every 3 months. The Kidney Disease Quality of Life Short Form was also administered.

RESULTS:

The mean of the difference in the IL-6 level between dialysers was 1.4 +/- 8.0 pg/ml (95% CI -1.8, 4.5 pg/ml). There was no significant difference in TNF-alpha (95% CI -0.35, 0.18 pg/ml) or CRP levels (95% CI -2.67, 6.20 mg/l). The quality of social interaction and role limitations caused by physical health problems were significantly higher with the FX60, p = 0.04 and 0.047, respectively.

CONCLUSIONS:

The FX dialysers do not result in a significant difference in the level of systemic inflammation compared to the HF80.

• Authors: Neil Boudville, Marilyn Horner, Elizabeth McEwan, Wai H Lim, David W Mudge, Hadley E Markus
• Journal: Blood purification (Blood Purif) Vol. 27 Issue 2 Pg. 187-93 ( 2009) ISSN: 1421-9735 [Electronic] Switzerland
• PMID: 19141998 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-6
• Recombinant Proteins
• Tumor Necrosis Factor-alpha
• Erythropoietin
• Darbepoetin alfa
• Epoetin Alfa
• C-Reactive Protein

Topics

• Adult
• Aged
• C-Reactive Protein (metabolism)
• Cross-Over Studies
• Darbepoetin alfa
• Epoetin Alfa
• Erythropoietin (administration & dosage, analogs & derivatives)
• Female
• Humans
• Inflammation (drug therapy)
• Interleukin-6 (metabolism)
• Male
• Middle Aged
• Quality of Life (psychology)
• Recombinant Proteins
• Renal Dialysis (instrumentation, psychology)
• Tumor Necrosis Factor-alpha (metabolism)