Abstract | CONTEXT: Elevated urinary albumin excretion has been reported in primary aldosteronism and might partially reflect reversible abnormalities initiated by glomerular hyperfiltration. OBJECTIVE: The aim of the study was to examine the outcome of renal function and intrarenal Doppler velocimetric indices in primary aldosteronism. DESIGN: SETTING: The study was conducted at a university referral center. PATIENTS: Fifty-four patients with tumoral or idiopathic aldosteronism were followed after either surgical (n = 24) or medical ( n = 30) treatment. Patients with primary aldosteronism were compared with 100 patients with primary hypertension and comparable severity and duration of disease. MAIN OUTCOME MEASURES: Changes in renal function and intrarenal echo-Doppler indices were measured. RESULTS: CONCLUSIONS: In primary aldosteronism, sonographic evidence of decreased intrarenal vascular resistance is associated with glomerular hyperfiltration. Both adrenalectomy and spironolactone revert the intrarenal hemodynamic pattern and decrease urinary protein losses.
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Authors | Leonardo A Sechi, Alessandro Di Fabio, Massimo Bazzocchi, Alessandro Uzzau, Cristiana Catena |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 94
Issue 4
Pg. 1191-7
(Apr 2009)
ISSN: 1945-7197 [Electronic] United States |
PMID | 19141581
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adrenalectomy
- Adult
- Aged
- Albuminuria
(etiology)
- Blood Pressure
- Female
- Heart Rate
- Hemodynamics
(physiology)
- Humans
- Hyperaldosteronism
(drug therapy, physiopathology, surgery, urine)
- Kidney Function Tests
- Kidney Glomerulus
(physiopathology)
- Male
- Middle Aged
- Prospective Studies
- Renal Circulation
(physiology)
- Spironolactone
(therapeutic use)
- Vascular Resistance
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