Endogenous lipid pneumonia in rats after subacute exposure to CdCl2.

Abstract

The objective of this report was to study lung cellular lesions in Wistar rats after subacute oral exposition to CdCl(2). The experimental groups were exposed to CdCl(2), through their drinking water in a concentration of 1 g/L, continuously for a period of 9 days. Histologically, all the exposed animals showed the incidence of interstitial pneumonia; hyperplasia of type II pneumocytes and Clara cells; the presence of foamy macrophages; and lesions linked to the existence of endogenous lipid pneumonia. Endogenous lipid pneumonia after CdCl(2) exposure has not been previously described; and in its pathogenesis, hyperplasia of type II pneumocytes and Clara cells activation could play an important role.

• Authors: A M Molina, A I Raya, L Carrasco, A Blanco, J G Monterde, A Rueda, R Moyano
• Journal: Toxicology and industrial health (Toxicol Ind Health) Vol. 24 Issue 10 Pg. 677-81 (Nov 2008) ISSN: 0748-2337 [Print] England
• PMID: 19141571 (Publication Type: Journal Article)

Chemical References

• Cadmium Chloride

Topics

• Animals
• Bronchioles (pathology, ultrastructure)
• Cadmium Chloride (toxicity)
• Cells, Cultured
• Data Interpretation, Statistical
• Female
• Foam Cells (pathology, ultrastructure)
• Hyperplasia (pathology)
• Lung (pathology)
• Male
• Pneumonia, Lipid (chemically induced, pathology)
• Pulmonary Alveoli (pathology, ultrastructure)
• Rats
• Rats, Wistar