Abstract | BACKGROUND: METHODS AND RESULTS: Nine biopsy specimens of ischemic muscles were obtained from five patients undergoing reconstructive vascular surgery. Biopsies from 35 normal subjects served as controls. Ischemic muscles showed a significant reduction in total carnitine from the control value of 20.9 +/- 5.2 to 11.6 +/- 6.2 nmol/mg noncollagen protein (p less than 0.01). A significantly lower free carnitine and acylcarnitine content contributed to this reduction. Similarly, carnitine acetyltransferase activity was reduced in the ischemic muscles from the control value of 102.1 +/- 41.2 to 52.9 +/- 22.1 nmol/min/mg noncollagen protein (p less than 0.01). On the contrary, carnitine palmitoyltransferase activity did not show any change (0.29 +/- 0.05 nmol/min/mg noncollagen protein in the ischemic muscles and 0.28 +/- 0.07 nmol/min/mg noncollagen protein in controls). Carnitine, acylcarnitines, and enzyme activities were also measured in the ischemic muscles in four additional patients 2 days after intravenous administration of L-propionylcarnitine (1.5 g as a single bolus followed by an infusion of 1 mg/kg/min for 30 minutes). Treatment restored normal levels of carnitine and its esters in the ischemic muscles but did not affect enzyme activities. CONCLUSIONS:
|
Authors | G Brevetti, C Angelini, M Rosa, R Carrozzo, S Perna, M Corsi, A Matarazzo, A Marcialis |
Journal | Circulation
(Circulation)
Vol. 84
Issue 4
Pg. 1490-5
(Oct 1991)
ISSN: 0009-7322 [Print] United States |
PMID | 1914091
(Publication Type: Journal Article)
|
Chemical References |
- propionylcarnitine
- Carnitine O-Palmitoyltransferase
- Carnitine O-Acetyltransferase
- Carnitine
|
Topics |
- Aged
- Carnitine
(analogs & derivatives, deficiency, therapeutic use)
- Carnitine O-Acetyltransferase
(metabolism)
- Carnitine O-Palmitoyltransferase
(metabolism)
- Humans
- Ischemia
(metabolism)
- Middle Aged
- Muscles
(blood supply, chemistry, enzymology)
- Peripheral Vascular Diseases
(drug therapy, metabolism)
|