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New amide derivatives as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.

Abstract
Melanin-concentrating hormone (MCH) is a recently discovered central nervous system (CNS) target for treating obesity. Two novel series of amide derivatives were synthesized and evaluated biologically as MCH-R1 (melanin-concentrating hormone receptor 1) antagonists. The results showed that diphenyl substituents on the amide lead to better activity than biphenyl substituents.
AuthorsNuria Cirauqui, Javier Ceras, Silvia Galiano, Silvia Pérez-Silanes, Laura Juanenea, Gildardo Rivera, Ignacio Aldana, Antonio Monge
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 58 Issue 11 Pg. 585-91 ( 2008) ISSN: 0004-4172 [Print] Germany
PMID19137910 (Publication Type: Journal Article)
Chemical References
  • Amides
  • Anti-Obesity Agents
  • Indicators and Reagents
  • MCHR1 protein, human
  • Receptors, Somatostatin
  • Solvents
Topics
  • Amides (chemical synthesis, pharmacology)
  • Animals
  • Anti-Obesity Agents (chemical synthesis, pharmacology)
  • CHO Cells
  • Cricetinae
  • Cricetulus
  • Humans
  • Indicators and Reagents
  • Receptors, Somatostatin (antagonists & inhibitors)
  • Solvents
  • Structure-Activity Relationship

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