HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Sequential intravenous and oral itraconazole in treatment of invasive fungal infection in hematological diseases].

AbstractOBJECTIVE:
We performed this study to investigate the efficacy and safety of sequential intravenous and oral itraconazole in the treatment of invasive fungal infection (IFI) in the patients with hematological diseases.
METHODS:
All the patients fit for the diagnostic criteria of IFI (proven diagnosis, probable diagnosis and possible diagnosis) with hematological diseases were entered into this study. The trial was designed as an open labeled, multi-centered study, with the total treatment duration of 4 - 6 weeks including intravenous and oral period. Intravenous itraconazole was given at the dose of 200 mg, twice a day in the first two days, and adjusted to 200 mg/d for subsequent 12 days. Sequential oral itraconazole was given at the dose of 200 mg, twice a day, for 2 - 4 weeks for maintenance therapy. Efficacy and safety evaluation was performed every 1 - 2 weeks according to the physician's decision.
RESULTS:
Two hundred and twenty seven patients were enrolled into this study. The overall response rate was 75.33% and the cure rate was 47.14%. Two hundred and five patients (205/227, 90.3%) defervesced after a median of 5 days (2 - 20 days). One hundred and eighty six patients were applicable for microbiological evaluation, among them, 69.89% responded to the treatment. Eleven treatment-related adverse events occurred during the study and none of them were severe adverse events.
CONCLUSION:
Sequential intravenous and oral itraconazole therapy was effective for IFI and tolerated well in patients with hematological diseases.
AuthorsGroup of Itraconazole Multi-Central Clinical Trial, Yu Chen, Zhi-xiang Shen
JournalZhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 47 Issue 12 Pg. 1026-9 (Dec 2008) ISSN: 0578-1426 [Print] China
PMID19134310 (Publication Type: English Abstract, Journal Article, Multicenter Study)
Chemical References
  • Antifungal Agents
  • Itraconazole
Topics
  • Administration, Oral
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antifungal Agents (administration & dosage, adverse effects, therapeutic use)
  • Female
  • Hematologic Diseases (complications, microbiology)
  • Humans
  • Injections, Intravenous
  • Itraconazole (administration & dosage, adverse effects, therapeutic use)
  • Male
  • Middle Aged
  • Mycoses (complications, drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: