Clinical use of recombinant human bone morphogenic protein-2 in a whooping crane (Grus americana).

Abstract

OBJECTIVE:

To report use of recombinant human bone morphogenetic protein-2 (rhBMP-2) as adjunctive therapy for treatment of a comminuted, open, proximal humeral fracture in an avian species.

STUDY DESIGN:

Clinical report.

ANIMALS:

A 3.5-month-old male whooping crane (Grus americana).

METHODS:

An open, severely comminuted humeral facture was stabilized with an intramuscular (IM) pin/type IA external skeletal fixator with tie-in configuration. rhBMP-2 was applied in a calcium phosphate matrix (CPM) paste directly to the fracture site as a bone graft substitute. Radiographic evidence of bone healing was monitored for 14 weeks.

RESULTS:

Substantial bony callus was evident at 4 weeks and at 8 weeks there was bridging callus with obvious bony remodeling. The fixation was destabilized at 9 weeks by IM pin removal, bone healing progressed and the fixator was removed at 11 weeks. By 14 weeks both cortices had been re-established with continued callus remodeling evident.

CONCLUSION:

rhBMP-2, applied in a CPM paste, was used as a bone graft substitute in the treatment of a comminuted, open humeral fracture in a whooping crane.

CLINICAL RELEVANCE:

Use of rhBMP-2/CPM should be considered in treatment of avian fractures.

• Authors: Susannah Sample, Gretchen Cole, Joanne Paul-Murphy, Barry K Hartup, Victoria Clyde, Howard J Seeherman, Susan Schaefer
• Journal: Veterinary surgery : VS (Vet Surg) Vol. 37 Issue 6 Pg. 552-7 (Aug 2008) ISSN: 1532-950X [Electronic] United States
• PMID: 19134105 (Publication Type: Case Reports, Journal Article)

Chemical References

• Bone Morphogenetic Protein 2
• Bone Morphogenetic Proteins
• Calcium Phosphates
• Recombinant Proteins
• Transforming Growth Factor beta
• recombinant human bone morphogenetic protein-2

Topics

• Animals
• Animals, Wild
• Birds (injuries, surgery)
• Bone Morphogenetic Protein 2
• Bone Morphogenetic Proteins (therapeutic use)
• Bony Callus (drug effects, physiology)
• Calcium Phosphates
• Fracture Fixation, Internal (instrumentation, methods, veterinary)
• Fracture Healing (drug effects, physiology)
• Fractures, Bone (surgery)
• Fractures, Comminuted (surgery)
• Humeral Fractures (surgery, veterinary)
• Male
• Recombinant Proteins (therapeutic use)
• Transforming Growth Factor beta (therapeutic use)
• Treatment Outcome