PPAR-delta in Vascular Pathophysiology.

Abstract

Peroxisome proliferator-activated receptors belong to the superfamily of ligand-dependent nuclear receptor transcription factors, which include three subtypes: PPAR-alpha, beta/delta, and gamma. PPAR-delta, play important roles in the regulation of cell growth and differentiation as well as tissue wound and repair. Emerging evidence has also demonstrated that PPAR-delta is implicated in lipids and glucose metabolism. Most recently, the direct effects of PPAR-delta on cardiovascular processes such as endothelial function and angiogenesis have also been investigated. Therefore, it is suggested that PPAR-delta may have critical roles in cardiovascular pathophysiology and is a potential target for therapeutic intervention of cardiovascular disorders such as atherosclerosis.

• Authors: Nanping Wang
• Journal: PPAR research (PPAR Res) Vol. 2008 Pg. 164163 ( 2008) ISSN: 1687-4757 [Print] United States
• PMID: 19132133 (Publication Type: Journal Article)