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[Macroamylasaemia in paediatrics].

Abstract
Macroamylasaemia should be considered in any patient with high plasma amylase, no clinical signs and negative additional investigations for pancreatic or parotid diseases. It is characterised by an increase in serum amylase due to circulating high molecular mass macrocomplexes, most often formed due the binding of the amylase to an immunoglobulin. With a normal renal function, a hyperamylasaemia without an increase in urine amylase suggests the diagnosis, and is confirmed by identifying the macromolecular components. It is an uncommon entity in paediatrics. It has been described as a casual finding associated to abdominal pain and to celiac disease. We report two paediatric cases of macroamylasaemia, and a review of the tests needed for its diagnosis. The better understanding of this biochemical anomaly allows us to differentiate it from other situations associated to hyperamylasaemia, in order to avoid additional invasive explorations and unnecessary treatments.
AuthorsA Torrent Vernetta, O Segarra Cantón, P Soler Palacín, R M Segura Cardona, D Infante Pina
JournalAnales de pediatria (Barcelona, Spain : 2003) (An Pediatr (Barc)) Vol. 69 Issue 5 Pg. 439-41 (Nov 2008) ISSN: 1695-4033 [Print] Spain
Vernacular TitleMacroamilasemia en pediatría.
PMID19128745 (Publication Type: Case Reports, English Abstract, Journal Article)
Topics
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Hyperamylasemia (diagnosis)
  • Male

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