Prenatal ultrasonographic findings in "trisomy 13".

Abstract

OBJECTIVE:

To evaluate the accuracy of prenatal ultrasonographic diagnosis in fetuses with trisomy 13.

MATERIAL METHOD:

The present study consisted of all fetuses diagnosed of trisomy 13 and delivered at Ramathibodi Hospital between 1997 and 2006.

RESULTS:

There were 15 cases of trisomy 13. Twelve cases (80.0%) were detected by prenatal ultrasonographic examination, and 3 cases (20.0%) were missed. Mean maternal age was 31.4 years old. Sixty-six percent were diagnosed in 2" trimester (mean 19.4 weeks). The earliest gestational age for detection was 12 weeks 6 days. The most common abnormal ultrasonographic findings were holoprosencephaly (46.7%), and facial defects (40.0%).

CONCLUSION:

The accuracy of prenatal sonographic diagnosis in trisomy 13 fetuses was 80%. The most sensitive prenatal ultrasonographic findings in trisomy 13 were holoprosencephaly and facial defects.

• Authors: Somsri Pitukkijronnakorn, Patama Promsonthi, Panyu Panburana, Rasig Rangsiprakarn, Apichart Chittacharoen
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 91 Issue 11 Pg. 1651-5 (Nov 2008) ISSN: 0125-2208 [Print] Thailand
• PMID: 19127784 (Publication Type: Journal Article)

Topics

• Adult
• Chromosome Aberrations
• Chromosomes, Human, Pair 13 (genetics)
• Face (abnormalities)
• Female
• Gestational Age
• Holoprosencephaly (diagnosis, genetics)
• Humans
• Pregnancy
• Risk Factors
• Trisomy (diagnosis, genetics)
• Ultrasonography, Prenatal (statistics & numerical data)