Abstract | BACKGROUND: THE AIMS OF OUR STUDY WERE: (1) to estimate the MMP-2 levels in the blood and tissues of patients with a groin hernia; (2) to answer the question of whether changes in MMP-2 activity correlate with the occurrence of inguinal hernias. METHOD: The study was performed on a group of 90 male patients suffering from inguinal hernias, aged 28-70 years (mean: 49 years). The control group was made up of 10 healthy (free from hernia) males, aged 30-68 years (mean: 46 years). RESULTS: We noticed increased levels of MMP-2 in patients with all types of hernia and across all age groups. The MMP-2 mean serum levels were statistically higher in patients with a groin hernia when compared to the control group. The highest blood levels of MMP-2 were observed in young men with a direct hernia. CONCLUSIONS: This study confirmed the important role of MMP-2 in the pathogenesis of inguinal hernia. The increased activity may lead to dysfunctions in collagen fiber, which is responsible for forming fascial structures, and as a result weaken their durability.
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Authors | J Smigielski, K Kołomecki, P Ziemniak, R Drozda, M Amsolik, K Kuzdak |
Journal | European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes
(Eur Surg Res)
Vol. 42
Issue 2
Pg. 118-21
( 2009)
ISSN: 1421-9921 [Electronic] Switzerland |
PMID | 19122458
(Publication Type: Journal Article)
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Copyright | Copyright (c) 2008 S. Karger AG, Basel. |
Chemical References |
- Collagen
- Matrix Metalloproteinase 2
|
Topics |
- Adult
- Age Factors
- Aged
- Case-Control Studies
- Collagen
(metabolism)
- Collagen Diseases
(blood, enzymology)
- Hernia, Abdominal
(blood, diagnosis, enzymology)
- Humans
- Male
- Matrix Metalloproteinase 2
(blood)
- Middle Aged
- Prognosis
- Prospective Studies
- Recurrence
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