Abstract | OBJECTIVE: STUDY DESIGN: Prospective, blinded study. ANIMALS: Ten male buffalo calves (6-8 months of age; body weight 70-90 kg) were used on two occasions to conduct a total of 20 investigations. METHODS: RESULTS: Extradural administration of xylazine or medetomidine resulted in complete analgesia of the tail, perineum, inguinal region and the upper parts of the hind limbs, which was faster in onset and longer in duration in the medetomidine group than in the xylazine group. Addition of bupivacaine increased the intensity of the analgesia produced by xylazine, but not that produced by medetomidine. All the drugs caused mild to moderate ataxia, but signs of sedation were apparent only in animals which received xylazine or medetomidine. The extradural injections of all the drugs caused significant decrease in heart rate (p = 0.024), respiratory rate (p = 0.026) and rectal temperature (p = 0.036) from the respective baseline values, but the differences between the groups were not significant. CONCLUSIONS: CLINICAL RELEVANCE:
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Authors | Virendra Singh, Amarpal, Prakash Kinjavdekar, Hari P Aithal |
Journal | Veterinary anaesthesia and analgesia
(Vet Anaesth Analg)
Vol. 36
Issue 1
Pg. 77-85
(Jan 2009)
ISSN: 1467-2995 [Electronic] United States |
PMID | 19121162
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Analgesics
- Xylazine
- Medetomidine
- Bupivacaine
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Topics |
- Analgesics
(administration & dosage, pharmacology)
- Animals
- Buffaloes
- Bupivacaine
(administration & dosage, pharmacology)
- Drug Interactions
- Drug Therapy, Combination
- Injections, Epidural
(veterinary)
- Male
- Medetomidine
(administration & dosage, pharmacology)
- Pain
(prevention & control)
- Time Factors
- Xylazine
(administration & dosage, pharmacology)
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