Abstract |
This study aimed to investigate whether carboxypeptidase-H antibody (CPH-Ab) can help identify latent autoimmune diabetes in adults (LADA). Phenotypic type 2 diabetic (T2D) patients (n= 1296) were studied for CPH Abs and autoantibodies to glutamic acid decarboxylase (GAD-Abs). CPH-Ab(+) T2D patients also underwent testing for insulinoma protein tyrosine phosphatase (IA-2A). Clinical features were compared among CPH-Ab(+), GAD-Ab(+), and Ab(-) T2D patients. Some of the antibody-positive patients were followed up for 3 years to assess beta cell function. The prevalence of CPH-Abs in T2D patients was 4.8%, significantly higher than that in controls. Double positivity was rare between CPH-Abs and GAD-Abs or IA-2A. Compared to patients with Ab(-) T2D, those with CPH-Ab(+) T2D had lower BMI, lower fasting C-peptide (FCP) levels, and more frequent ketosis, while not as much as did those with GAD-Ab(+) T2D. The mild beta cell dysfunction in patients with CPH-Ab(+) T2D was associated with their longer duration of diabetes. No marked change of C-peptide in the CPH-Ab(+) group was found during follow-up. These findings demonstrated that CPH-Abs may allow discrimination of a more latent subset of adult-onset autoimmune diabetes (LADA) whose features are intermediate between those with classic GAD-Ab(+) LADA and patients with Ab(-) T2D.
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Authors | L Yang, Z G Zhou, S Z Tan, G Huang, P Jin, X Yan, X Li, H Peng, W Hagopian |
Journal | Annals of the New York Academy of Sciences
(Ann N Y Acad Sci)
Vol. 1150
Pg. 263-6
(Dec 2008)
ISSN: 1749-6632 [Electronic] United States |
PMID | 19120309
(Publication Type: Comparative Study, Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Carboxypeptidase H
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Topics |
- Adult
- Age of Onset
- Aged
- Autoantibodies
(blood, physiology)
- Carboxypeptidase H
(immunology)
- Case-Control Studies
- China
(epidemiology)
- Diabetes Mellitus, Type 1
(blood, diagnosis, epidemiology, immunology)
- Diabetes Mellitus, Type 2
(blood, diagnosis, epidemiology, immunology)
- Diagnosis, Differential
- Female
- Follow-Up Studies
- Humans
- Islets of Langerhans
(physiology)
- Male
- Middle Aged
- Phenotype
- Seroepidemiologic Studies
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