Abstract | BACKGROUND: Selected lactic acid bacteria were reported to prevent atopic dermatitis and experimental asthma but the mechanisms of their immunomodulatory effects are not fully elucidated. In this study, the signaling pathways triggered by Lactobacillus plantarum NCIMB8826 were investigated and the potential use of this strain producing a variant of the mite allergen Der p 1 as live vaccine vehicle was evaluated. METHODS: Mouse bone marrow-derived dendritic cells were stimulated with wild-type or a L. plantarum teichoic acid mutant to evaluate the secretion of cytokines. A recombinant L. plantarum expressing Der p 1 was engineered, its in vitro immunomodulatory properties were characterized and its prophylactic potential was evaluated in a Der p 1-sensitization murine model. RESULTS: CONCLUSION:
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Authors | P Rigaux, C Daniel, M Hisbergues, E Muraille, P Hols, B Pot, J Pestel, A Jacquet |
Journal | Allergy
(Allergy)
Vol. 64
Issue 3
Pg. 406-14
(Mar 2009)
ISSN: 1398-9995 [Electronic] Denmark |
PMID | 19120072
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, Dermatophagoides
- Arthropod Proteins
- Lipopolysaccharides
- TLR2 protein, human
- Teichoic Acids
- Toll-Like Receptor 2
- Toll-Like Receptor 9
- Vaccines, Synthetic
- lipoteichoic acid
- Cysteine Endopeptidases
- Dermatophagoides pteronyssinus antigen p 1
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Topics |
- Animals
- Antigens, Dermatophagoides
(immunology)
- Arthropod Proteins
- Cysteine Endopeptidases
- Dendritic Cells
(immunology)
- Humans
- Hypersensitivity
(prevention & control)
- Immunoblotting
- Lactobacillus plantarum
(immunology)
- Lipopolysaccharides
(immunology)
- Mice
- Mice, Inbred BALB C
- Mites
(immunology)
- Signal Transduction
(immunology)
- Teichoic Acids
(immunology)
- Toll-Like Receptor 2
(immunology)
- Toll-Like Receptor 9
(immunology)
- Transfection
- Vaccines, Synthetic
(immunology)
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