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Failure of cloxacillin in treatment of a patient with borderline oxacillin-resistant Staphylococcus aureus endocarditis.

Abstract
Clinical evidence for failure with beta-lactam therapy has been lacking for patients with borderline oxacillin-resistant Staphylococcus aureus (BORSA) infections. We describe a failure of cloxacillin for a patient with endocarditis due to BORSA. The isolate also had false-negative thermonuclease and coagulase test results.
AuthorsStuart Skinner, Melanie Murray, Tom Walus, James A Karlowsky
JournalJournal of clinical microbiology (J Clin Microbiol) Vol. 47 Issue 3 Pg. 859-61 (Mar 2009) ISSN: 1098-660X [Electronic] United States
PMID19116360 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Coagulase
  • Micrococcal Nuclease
  • Cloxacillin
  • Oxacillin
Topics
  • Adult
  • Anti-Bacterial Agents (pharmacology, therapeutic use)
  • Cloxacillin (therapeutic use)
  • Coagulase (analysis)
  • Drug Resistance, Bacterial
  • Endocarditis, Bacterial (drug therapy, microbiology)
  • Humans
  • Micrococcal Nuclease (analysis)
  • Oxacillin (pharmacology)
  • Staphylococcal Infections (drug therapy, microbiology)
  • Staphylococcus aureus (drug effects, enzymology, isolation & purification)

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