Abstract |
Progressive degeneration of striatal projection neurons is thought to account for the loss of L-Dopa response observed in the majority of patients with the parkinsonian variant of multiple system atrophy (MSA-P). Here we have investigated the effects of E14 embryonic striatal allografts on dopaminergic responsiveness in the unilateral double-lesion rat model of MSA-P by using tests of complex motor behavior. Both sham and graft animals showed an increase in apomorphine-induced rotations as well as an improvement in cylinder test performance following surgical intervention. In contrast, L-Dopa responsiveness of stepping behavior was improved only in grafted animals. The restoration of apomorphine-induced rotation correlated with the P-zone volume of grafts. Our findings indicate that transplantation of embryonic striatal grafts might, at least to some extent, restore responsiveness to L-Dopa in tasks of complex motor behavior. Therefore, striatal transplantation should be further defined preclinically as a possible therapeutic option for patients with MSA-P and a failing L-Dopa response.
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Authors | Martin Köllensperger, Nadia Stefanova, Anton Pallua, Zoe Puschban, Georg Dechant, Monika Hainzer, Markus Reindl, Werner Poewe, Guido Nikkhah, Gregor K Wenning |
Journal | Journal of neuroscience research
(J Neurosci Res)
Vol. 87
Issue 7
Pg. 1679-85
(May 15 2009)
ISSN: 1097-4547 [Electronic] United States |
PMID | 19115416
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2008 Wiley-Liss, Inc. |
Chemical References |
- Dopamine Agents
- Levodopa
- Apomorphine
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Topics |
- Analysis of Variance
- Animals
- Apomorphine
(pharmacology)
- Brain
(pathology)
- Corpus Striatum
(embryology, transplantation)
- Disease Models, Animal
- Dopamine Agents
(therapeutic use)
- Levodopa
(therapeutic use)
- Male
- Motor Activity
(drug effects)
- Multiple System Atrophy
(drug therapy, physiopathology, therapy)
- Random Allocation
- Rats
- Rats, Wistar
- Transplantation, Homologous
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