Abstract | BACKGROUND: Acute ketamine has been shown to model features of schizophrenia such as psychotic symptoms, cognitive deficits and smooth pursuit eye movement dysfunction. There have been suggestions that chronic ketamine may also produce an analogue of the disorder. In this study, we investigated the effect of persistent recreational ketamine use on tests of episodic and working memory and on oculomotor tasks of smooth pursuit and pro- and antisaccades. METHODS: Twenty ketamine users were compared with 1) 20 first-episode schizophrenia patients, 2) 17 polydrug control subjects who did not use ketamine but were matched to the ketamine users for other drug use, and 3) 20 non- drug-using control subjects. All groups were matched for estimated premorbid IQ. RESULTS:
Ketamine users made more antisaccade errors than both control groups but did not differ from patients. Ketamine users performed better than schizophrenia patients on smooth pursuit, antisaccade metrics, and both memory tasks but did not differ from control groups. CONCLUSIONS:
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Authors | Celia J A Morgan, Vyv Huddy, Michelle Lipton, H Valerie Curran, Eileen M Joyce |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 65
Issue 12
Pg. 1099-102
(Jun 15 2009)
ISSN: 1873-2402 [Electronic] United States |
PMID | 19111280
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Excitatory Amino Acid Antagonists
- Ketamine
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Topics |
- Adolescent
- Adult
- Cognition Disorders
(chemically induced, psychology)
- Excitatory Amino Acid Antagonists
- Female
- Humans
- Intelligence Tests
- Ketamine
- Male
- Memory, Short-Term
(physiology)
- Middle Aged
- Neuropsychological Tests
- Ocular Motility Disorders
(chemically induced, psychology)
- Psychomotor Performance
(physiology)
- Pursuit, Smooth
(physiology)
- Schizophrenic Psychology
- Space Perception
(physiology)
- Substance-Related Disorders
(psychology)
- Verbal Learning
- Young Adult
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